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SPINT2 inhibits proteases involved in activation of both influenza viruses and metapneumoviruses

Viruses possessing class I fusion proteins require proteolytic activation by host cell proteases to mediate fusion with the host cell membrane. The mammalian SPINT2 gene encodes a protease inhibitor that targets trypsin-like serine proteases. Here we show the protease inhibitor, SPINT2, restricts cl...

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Bibliografiske detaljer
Udgivet i:Virology
Main Authors: Straus, Marco R., Kinder, Jonathan T., Segall, Michal, Dutch, Rebecca Ellis, Whittaker, Gary R.
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier Inc. 2020
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7112099/
https://ncbi.nlm.nih.gov/pubmed/32056846
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.virol.2020.01.004
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