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Inhibition of Human Metapneumovirus Binding to Heparan Sulfate Blocks Infection in Human Lung Cells and Airway Tissues

Human metapneumovirus (HMPV), a recently discovered paramyxovirus, infects nearly 100% of the world population and causes severe respiratory disease in infants, the elderly, and immunocompromised patients. We previously showed that HMPV binds heparan sulfate proteoglycans (HSPGs) and that HMPV bindi...

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Pubblicato in:J Virol
Autori principali: Klimyte, Edita M., Smith, Stacy E., Oreste, Pasqua, Lembo, David, Dutch, Rebecca Ellis
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2016
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5044844/
https://ncbi.nlm.nih.gov/pubmed/27489270
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01362-16
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