Palmitoylation of the Alphacoronavirus TGEV spike protein S is essential for incorporation into virus-like particles but dispensable for S–M interaction

The spike protein S of coronaviruses contains a highly conserved cytoplasmic cysteine-rich motif adjacent to the transmembrane region. This motif is palmitoylated in the Betacoronaviruses MHV and SARS-CoV. Here, we demonstrate by metabolic labeling with [(3)H]-palmitic acid that the S protein of tra...

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Detalhes bibliográficos
Publicado no:Virology
Main Authors: Gelhaus, Sandra, Thaa, Bastian, Eschke, Kathrin, Veit, Michael, Schwegmann-Weßels, Christel
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier Inc. 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7112097/
https://ncbi.nlm.nih.gov/pubmed/25113909
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.virol.2014.07.035
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