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A mature and fusogenic form of the Nipah virus fusion protein requires proteolytic processing by cathepsin L
The Nipah virus fusion (F) protein is proteolytically processed to F(1) + F(2) subunits. We demonstrate here that cathepsin L is involved in this important maturation event. Cathepsin inhibitors ablated cleavage of Nipah F. Proteolytic processing of Nipah F and fusion activity was dramatically reduc...
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| 發表在: | Virology |
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| Main Authors: | , , , |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
Elsevier Inc.
2006
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7111743/ https://ncbi.nlm.nih.gov/pubmed/16460775 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.virol.2006.01.007 |
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