Inhibition of CRM1-mediated nuclear export of influenza A nucleoprotein and nuclear export protein as a novel target for antiviral drug development

An anti-influenza compound, DP2392-E10 based on inhibition of the nuclear export function of the viral nucleoprotein-nuclear export signal 3 (NP-NES3) domain was successfully identified by our previous high-throughput screening system. Here, we demonstrated that DP2392-E10 exerts its antiviral effec...

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Veröffentlicht in:Virology
Hauptverfasser: Chutiwitoonchai, Nopporn, Mano, Takafumi, Kakisaka, Michinori, Sato, Hirotaka, Kondoh, Yasumitsu, Osada, Hiroyuki, Kotani, Osamu, Yokoyama, Masaru, Sato, Hironori, Aida, Yoko
Format: Artigo
Sprache:Inglês
Veröffentlicht: Elsevier Inc. 2017
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7111614/
https://ncbi.nlm.nih.gov/pubmed/28399435
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.virol.2017.04.001
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