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Critical roles of phosphoinositides and NF2 in Hippo pathway regulation

The Hippo pathway is a master regulator of tissue homeostasis and organ size. NF2 is a well-established tumor suppressor, and loss of NF2 severely compromises Hippo pathway activity. However, the precise mechanism of how NF2 mediates upstream signals to regulate the Hippo pathway is not clear. Here...

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Podrobná bibliografie
Vydáno v:Genes Dev
Hlavní autoři: Hong, Audrey W., Meng, Zhipeng, Plouffe, Steven W., Lin, Zhijie, Zhang, Mingjie, Guan, Kun-Liang
Médium: Artigo
Jazyk:Inglês
Vydáno: Cold Spring Harbor Laboratory Press 2020
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7111263/
https://ncbi.nlm.nih.gov/pubmed/32115406
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.333435.119
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