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Critical roles of phosphoinositides and NF2 in Hippo pathway regulation

The Hippo pathway is a master regulator of tissue homeostasis and organ size. NF2 is a well-established tumor suppressor, and loss of NF2 severely compromises Hippo pathway activity. However, the precise mechanism of how NF2 mediates upstream signals to regulate the Hippo pathway is not clear. Here...

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Detalhes bibliográficos
Publicado no:Genes Dev
Main Authors: Hong, Audrey W., Meng, Zhipeng, Plouffe, Steven W., Lin, Zhijie, Zhang, Mingjie, Guan, Kun-Liang
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2020
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7111263/
https://ncbi.nlm.nih.gov/pubmed/32115406
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.333435.119
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