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QM/QM studies for Michael reaction in coronavirus main protease (3CL(Pro))

Severe acute respiratory syndrome (SARS) is an illness caused by a novel corona virus wherein the main proteinase called 3CL(Pro) has been established as a target for drug design. The mechanism of action involves nucleophilic attack by Cys145 present in the active site on the carbonyl carbon of the...

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Detalhes bibliográficos
Publicado no:J Mol Graph Model
Main Authors: Taranto, Alex G., Carvalho, Paulo, Avery, Mitchell A.
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier Inc. 2008
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7110475/
https://ncbi.nlm.nih.gov/pubmed/18567519
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmgm.2008.05.002
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