Structure of a Herpesvirus-Encoded Cysteine Protease Reveals a Unique Class of Deubiquitinating Enzymes

All members of the herpesviridae contain within their large tegument protein a cysteine protease module that displays deubiquitinating activity. We report the crystal structure of the cysteine protease domain of murine cytomegalovirus M48 (M48(USP)) in a complex with a ubiquitin (Ub)-based suicide s...

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Udgivet i:Mol Cell
Main Authors: Schlieker, Christian, Weihofen, Wilhelm A., Frijns, Evelyne, Kattenhorn, Lisa M., Gaudet, Rachelle, Ploegh, Hidde L.
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier Inc. 2007
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7110467/
https://ncbi.nlm.nih.gov/pubmed/17349955
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2007.01.033
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