Significance of the Myxovirus Resistance A (MxA) Gene — 123C>A Single-Nucleotide Polymorphism in Suppressed Interferon β Induction of Severe Acute Respiratory Syndrome Coronavirus Infection

Myxovirus resistance A (MxA) is an antiviral protein induced by interferon α and β (IFN-α, IFN-β) that can inhibit viral replication. The minor alleles of the -88G>T and -123C>A MxA promoter single-nucleotide polymorphisms (SNPs) are associated with increased promoter activity and altered resp...

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Detalhes bibliográficos
Publicado no:J Infect Dis
Main Authors: Ching, Johannes Chi-Yun, Chan, Kelvin Yuen Kwong, Lee, Eric Hing Leung, Xu, Mei-Shu, Ting, Campbell Kam Po, So, Thomas M. K., Sham, Pak C., Leung, Gabriel M., Peiris, Joseph S. M., Khoo, Ui-Soon
Formato: Artigo
Idioma:Inglês
Publicado em: The University of Chicago Press 2010
Assuntos:
Major Articles And Brief Reports
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7109798/
https://ncbi.nlm.nih.gov/pubmed/20462354
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1086/652799
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