Myxovirus Resistance Gene A (MxA) Expression Suppresses Influenza A Virus Replication in Alpha Interferon-Treated Primate Cells

Alpha interferon (IFN-α) production is triggered when influenza virus RNA is detected by appropriate pattern recognition receptors in the host cell. IFN-α induces the expression of more than 300 interferon-stimulated genes (ISGs), and this blunts influenza virus replication. The human ISG MxA can in...

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Detalhes bibliográficos
Main Authors: Matzinger, Shannon R., Carroll, Timothy D., Dutra, Joseph C., Ma, Zhong-Min, Miller, Christopher J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2013
Assuntos:
Pathogenesis and Immunity
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3554078/
https://ncbi.nlm.nih.gov/pubmed/23152507
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02271-12
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