Glutathione peroxidase 4 and vitamin E control reticulocyte maturation, stress erythropoiesis and iron homeostasis

Glutathione peroxidase 4 (GPX4) is unique as it is the only enzyme that can prevent detrimental lipid peroxidation in vivo by reducing lipid peroxides to the respective alcohols thereby stabilizing oxidation products of unsaturated fatty acids. During reticulocyte maturation, lipid peroxidation medi...

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Publicado no:Haematologica
Main Authors: Altamura, Sandro, Vegi, Naidu M., Hoppe, Philipp S., Schroeder, Timm, Aichler, Michaela, Walch, Axel, Okreglicka, Katarzyna, Hültner, Lothar, Schneider, Manuela, Ladinig, Camilla, Kuklik-Roos, Cornelia, Mysliwietz, Josef, Janik, Dirk, Neff, Frauke, Rathkolb, Birgit, de Angelis, Mar tin Hrabé, Buske, Christian, da Silva, Ana Rita, Muedder, Katja, Conrad, Marcus, Ganz, Tomas, Kopf, Manfred, Muckenthaler, Martina U., Bornkamm, Georg W.
Formato: Artigo
Idioma:Inglês
Publicado em: Ferrata Storti Foundation 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7109755/
https://ncbi.nlm.nih.gov/pubmed/31248967
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3324/haematol.2018.212977
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