Mechanisms of increased mitochondria-dependent necrosis in Wiskott-Aldrich syndrome platelets

Wiskott-Aldrich syndrome (WAS) is associated with thrombocytopenia of unclear origin. We investigated real-time cytosolic calcium dynamics, mitochondrial membrane potential and phoszphatidylserine (PS) exposure in single fibrinogen-bound platelets using confocal microscopy. The WAS platelets had hig...

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Publicado en:Haematologica
Main Authors: Obydennyi, Sergey I., Artemenko, Elena O., Sveshnikova, Anastasia N., Ignatova, Anastasia A., Varlamova, Tatiana V., Gambaryan, Stepan, Lomakina, Galina Y., Ugarova, Natalia N., Kireev, Igor I., Ataullakhanov, Fazoil I., Novichkova, Galina A., Maschan, Aleksey A., Shcherbina, Anna, Panteleev, Mikhail
Formato: Artigo
Idioma:Inglês
Publicado: Ferrata Storti Foundation 2020
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7109739/
https://ncbi.nlm.nih.gov/pubmed/31278208
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3324/haematol.2018.214460
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