Mechanisms of increased mitochondria-dependent necrosis in Wiskott-Aldrich syndrome platelets

Wiskott-Aldrich syndrome (WAS) is associated with thrombocytopenia of unclear origin. We investigated real-time cytosolic calcium dynamics, mitochondrial membrane potential and phoszphatidylserine (PS) exposure in single fibrinogen-bound platelets using confocal microscopy. The WAS platelets had hig...

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Publicat a:Haematologica
Autors principals: Obydennyi, Sergey I., Artemenko, Elena O., Sveshnikova, Anastasia N., Ignatova, Anastasia A., Varlamova, Tatiana V., Gambaryan, Stepan, Lomakina, Galina Y., Ugarova, Natalia N., Kireev, Igor I., Ataullakhanov, Fazoil I., Novichkova, Galina A., Maschan, Aleksey A., Shcherbina, Anna, Panteleev, Mikhail
Format: Artigo
Idioma:Inglês
Publicat: Ferrata Storti Foundation 2020
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7109739/
https://ncbi.nlm.nih.gov/pubmed/31278208
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3324/haematol.2018.214460
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