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Simultaneous tracers and a unified model of positional and mass isotopomers for quantification of metabolic flux in liver

Computational models based on the metabolism of stable isotope tracers can yield valuable insight into the metabolic basis of disease. The complexity of these models is limited by the number of tracers and the ability to characterize tracer labeling in downstream metabolites. NMR spectroscopy is ide...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Veröffentlicht in:Metab Eng
Hauptverfasser: Deja, Stanislaw, Fu, Xiaorong, Fletcher, Justin A., Kucejova, Blanka, Browning, Jeffrey D., Young, Jamey D., Burgess, Shawn C.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2019
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7108978/
https://ncbi.nlm.nih.gov/pubmed/31891762
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ymben.2019.12.005
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