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Bruton tyrosine kinase deficiency augments NLRP3 inflammasome activation and causes IL-1β–mediated colitis

Bruton tyrosine kinase (BTK) is present in a wide variety of cells and may thus have important non–B cell functions. Here, we explored the function of this kinase in macrophages with studies of its regulation of the NLR family, pyrin domain–containing 3 (NLRP3) inflammasome. We found that bone marro...

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Podrobná bibliografie
Vydáno v:J Clin Invest
Hlavní autoři: Mao, Liming, Kitani, Atsushi, Hiejima, Eitaro, Montgomery-Recht, Kim, Zhou, Wenchang, Fuss, Ivan, Wiestner, Adrian, Strober, Warren
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Clinical Investigation 2020
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7108929/
https://ncbi.nlm.nih.gov/pubmed/31895698
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI128322
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