A NLRP3 Mutation Causing inflammasome Hyperactivation Potentiates Th17-Dominant Immune Responses

Missense mutations of NLRP3 gene (CIAS1) are associated with autoinflammatory disorders characterized with excessive production of IL-1β. Here we analyzed the immune responses of knock-in mice carrying a point mutation of NLRP3 associated with Muckle-Wells Syndrome. We found that antigen presenting...

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Bibliographic Details
Main Authors: Meng, Guangxun, Zhang, Fuping, Fuss, Ivan, Kitani, Atsushi, Strober, Warren
Format: Artigo
Language:Inglês
Published: 2009
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2764254/
https://ncbi.nlm.nih.gov/pubmed/19501001
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2009.04.012
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