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A NLRP3 Mutation Causing inflammasome Hyperactivation Potentiates Th17-Dominant Immune Responses
Missense mutations of NLRP3 gene (CIAS1) are associated with autoinflammatory disorders characterized with excessive production of IL-1β. Here we analyzed the immune responses of knock-in mice carrying a point mutation of NLRP3 associated with Muckle-Wells Syndrome. We found that antigen presenting...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2764254/ https://ncbi.nlm.nih.gov/pubmed/19501001 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2009.04.012 |
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