Angiopoietin-2 blockade ameliorates autoimmune neuroinflammation by inhibiting leukocyte recruitment into the CNS

Angiopoietin-2 (Ang2), a ligand of the endothelial Tie2 tyrosine kinase, is involved in vascular inflammation and leakage in critically ill patients. However, the role of Ang2 in demyelinating central nervous system (CNS) autoimmune diseases is unknown. Here, we report that Ang2 is critically involv...

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Enregistré dans:
Détails bibliographiques
Publié dans:J Clin Invest
Auteurs principaux: Li, Zhilin, Korhonen, Emilia A., Merlini, Arianna, Strauss, Judith, Wihuri, Eleonoora, Nurmi, Harri, Antila, Salli, Paech, Jennifer, Deutsch, Urban, Engelhardt, Britta, Chintharlapalli, Sudhakar, Koh, Gou Young, Flügel, Alexander, Alitalo, Kari
Format: Artigo
Langue:Inglês
Publié: American Society for Clinical Investigation 2020
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7108925/
https://ncbi.nlm.nih.gov/pubmed/32149735
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI130308
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