Angiopoietin-2 blockade ameliorates autoimmune neuroinflammation by inhibiting leukocyte recruitment into the CNS

Angiopoietin-2 (Ang2), a ligand of the endothelial Tie2 tyrosine kinase, is involved in vascular inflammation and leakage in critically ill patients. However, the role of Ang2 in demyelinating central nervous system (CNS) autoimmune diseases is unknown. Here, we report that Ang2 is critically involv...

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Detalhes bibliográficos
Publicado no:J Clin Invest
Main Authors: Li, Zhilin, Korhonen, Emilia A., Merlini, Arianna, Strauss, Judith, Wihuri, Eleonoora, Nurmi, Harri, Antila, Salli, Paech, Jennifer, Deutsch, Urban, Engelhardt, Britta, Chintharlapalli, Sudhakar, Koh, Gou Young, Flügel, Alexander, Alitalo, Kari
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2020
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7108925/
https://ncbi.nlm.nih.gov/pubmed/32149735
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI130308
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