Protein arginine methyltransferase 5 promotes cholesterol biosynthesis–mediated Th17 responses and autoimmunity

Protein arginine methyltransferase 5 (PRMT5) catalyzes symmetric dimethylation (SDM) of arginine, a posttranslational modification involved in oncogenesis and embryonic development. However, the role and mechanisms by which PRMT5 modulates Th cell polarization and autoimmune disease have not yet bee...

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Pubblicato in:J Clin Invest
Autori principali: Webb, Lindsay M., Sengupta, Shouvonik, Edell, Claudia, Piedra-Quintero, Zayda L., Amici, Stephanie A., Miranda, Janiret Narvaez, Bevins, Makenzie, Kennemer, Austin, Laliotis, Georgios, Tsichlis, Philip N., Guerau-de-Arellano, Mireia
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Clinical Investigation 2020
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7108896/
https://ncbi.nlm.nih.gov/pubmed/32091410
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI131254
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