NF-κB/mTOR/MYC Axis Drives PRMT5 Protein Induction After T Cell Activation via Transcriptional and Non-transcriptional Mechanisms

Multiple sclerosis is an autoimmune disease of the central nervous system (CNS) mediated by CD4(+) T cells and modeled via experimental autoimmune encephalomyelitis (EAE). Inhibition of PRMT5, the major Type II arginine methyltransferase, suppresses pathogenic T cell responses and EAE. PRMT5 is tran...

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Detalhes bibliográficos
Publicado no:Front Immunol
Main Authors: Webb, Lindsay M., Narvaez Miranda, Janiret, Amici, Stephanie A., Sengupta, Shouvonik, Nagy, Gregory, Guerau-de-Arellano, Mireia
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2019
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6433977/
https://ncbi.nlm.nih.gov/pubmed/30941147
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2019.00524
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