Therapeutic IDOL Reduction Ameliorates Amyloidosis and Improves Cognitive Function in APP/PS1 Mice

Brain lipoprotein receptors have been shown to regulate the metabolism of ApoE and β-amyloid (Aβ) and are potential therapeutic targets for Alzheimer’s disease (AD). Previously, we identified E3 ubiquitin ligase IDOL as a negative regulator of brain lipoprotein receptors. Genetic ablation of Idol in...

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Tallennettuna:
Bibliografiset tiedot
Julkaisussa:Mol Cell Biol
Päätekijät: Gao, Jie, Littman, Russell, Diamante, Graciel, Xiao, Xu, Ahn, In Sook, Yang, Xia, Cole, Tracy A., Tontonoz, Peter
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: American Society for Microbiology 2020
Aiheet:
Research Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC7108818/
https://ncbi.nlm.nih.gov/pubmed/31964754
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00518-19
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