Active Replication of Middle East Respiratory Syndrome Coronavirus and Aberrant Induction of Inflammatory Cytokines and Chemokines in Human Macrophages: Implications for Pathogenesis

Middle East respiratory syndrome coronavirus (MERS-CoV) infection caused severe pneumonia and multiorgan dysfunction and had a higher crude fatality rate (around 50% vs 10%) than SARS coronavirus (SARS-CoV) infection. To understand the pathogenesis, we studied viral replication, cytokine/chemokine r...

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Dettagli Bibliografici
Pubblicato in:J Infect Dis
Autori principali: Zhou, Jie, Chu, Hin, Li, Cun, Wong, Bosco Ho-Yin, Cheng, Zhong-Shan, Poon, Vincent Kwok-Man, Sun, Tianhao, Lau, Candy Choi-Yi, Wong, Kenneth Kak-Yuen, Chan, Jimmy Yu-Wai, Chan, Jasper Fuk-Woo, To, Kelvin Kai-Wang, Chan, Kwok-Hung, Zheng, Bo-Jian, Yuen, Kwok-Yung
Natura: Artigo
Lingua:Inglês
Pubblicazione: Oxford University Press 2014
Soggetti:
Major Articles and Brief Reports
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7107356/
https://ncbi.nlm.nih.gov/pubmed/24065148
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/infdis/jit504
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