Conformational Changes Induced by S34Y and R98C Variants in the Death Domain of Myd88

Myeloid differentiating factor 88 (Myd88) is a universal adaptor protein that plays a critical role in innate immunity by mediating TLR downstream signaling. Myd88 death domain (DD) forms an oligomeric complex by association with other DD-containing proteins such as IRAK4. Despite its universal role...

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Detalles Bibliográficos
Publicado en:Front Mol Biosci
Autores principales: Gosu, Vijayakumar, Won, KyeongHye, Oh, Jae-Don, Shin, Donghyun
Formato: Artigo
Lenguaje:Inglês
Publicado: Frontiers Media S.A. 2020
Materias:
Molecular Biosciences
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7106778/
https://ncbi.nlm.nih.gov/pubmed/32266286
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fmolb.2020.00027
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