Laminin 221 fragment is suitable for the differentiation of human induced pluripotent stem cells into brain microvascular endothelial-like cells with robust barrier integrity

BACKGROUND: In vitro blood–brain barrier (BBB) models using human induced pluripotent stem (iPS) cell-derived brain microvascular endothelial-like cells (iBMELCs) have been developed to predict the BBB permeability of drug candidates. For the differentiation of iBMELCs, Matrigel, which is a gelatino...

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Dettagli Bibliografici
Pubblicato in:Fluids Barriers CNS
Autori principali: Aoki, Hiromasa, Yamashita, Misaki, Hashita, Tadahiro, Iwao, Takahiro, Matsunaga, Tamihide
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2020
Soggetti:
Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7106710/
https://ncbi.nlm.nih.gov/pubmed/32228708
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12987-020-00186-4
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