A Novel Class of Common Docking Domain Inhibitors That Prevent ERK2 Activation and Substrate Phosphorylation

Extracellular signal-regulated kinases (ERK1/2) are mitogen-activated protein kinases (MAPKs) that play a pro-tumorigenic role in numerous cancers. ERK1/2 possess two protein-docking sites that are distinct from the active site: the D-recruitment site (DRS) and the F-recruitment site. These docking...

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Veröffentlicht in:ACS Chem Biol
Hauptverfasser: Sammons, Rachel M., Perry, Nicole A., Li, Yangmei, Cho, Eun Jeong, Piserchio, Andrea, Zamora-Olivares, Diana P., Ghose, Ranajeet, Kaoud, Tamer S., Debevec, Ginamarie, Bartholomeusz, Chandra, Gurevich, Vsevolod V., Iverson, Tina M., Giulianotti, Marc, Houghten, Richard A., Dalby, Kevin N.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2019
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7105935/
https://ncbi.nlm.nih.gov/pubmed/31058487
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschembio.9b00093
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