Computational Design of High-Affinity Epitope Scaffolds by Backbone Grafting of a Linear Epitope

Computational grafting of functional motifs onto scaffold proteins is a promising way to engineer novel proteins with pre-specified functionalities. Typically, protein grafting involves the transplantation of protein side chains from a functional motif onto structurally homologous regions of scaffol...

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Dades bibliogràfiques
Publicat a:J Mol Biol
Autors principals: Azoitei, Mihai L., Ban, Yih-En Andrew, Julien, Jean-Philippe, Bryson, Steve, Schroeter, Alexandria, Kalyuzhniy, Oleksandr, Porter, Justin R., Adachi, Yumiko, Baker, David, Pai, Emil F., Schief, William R.
Format: Artigo
Idioma:Inglês
Publicat: Elsevier Ltd. 2012
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7105911/
https://ncbi.nlm.nih.gov/pubmed/22061265
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2011.10.003
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