Roscovitine enhances all-trans retinoic acid (ATRA)-induced nuclear enrichment of an ensemble of activated signaling molecules and augments ATRA-induced myeloid cell differentiation

Although ATRA represents a successful differentiation therapy for APL, it is largely ineffective for non-APL AMLs. Hence combination therapies using an agent targeting ATRA-regulated molecules that drive cell differentiation/arrest are of interest. Using the HL-60 human non-APL AML model where ATRA...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Oncotarget
Egile Nagusiak: Rashid, Asif, Duan, Xin, Gao, Feng, Yang, Mengsu, Yen, Andrew
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Impact Journals LLC 2020
Gaiak:
Research Paper
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC7105165/
https://ncbi.nlm.nih.gov/pubmed/32256976
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.27508
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