Wwox deletion leads to reduced GABA-ergic inhibitory interneuron numbers and activation of microglia and astrocytes in mouse hippocampus

The association of WW domain-containing oxidoreductase WWOX gene loss of function with central nervous system (CNS) related pathologies is well documented. These include spinocerebellar ataxia, epilepsy and mental retardation (SCAR12, OMIM: 614322) and early infantile epileptic encephalopathy (EIEE2...

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Veröffentlicht in:Neurobiol Dis
Hauptverfasser: Hussain, Tabish, Kil, Hyunsuk, Hattiangady, Bharathi, Lee, Jaeho, Kodali, Maheedhar, Shuai, Bing, Attaluri, Sahithi, Takata, Yoko, Shen, Jianjun, Abba, Martin C., Shetty, Ashok K., Aldaz, C. Marcelo
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2018
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7104842/
https://ncbi.nlm.nih.gov/pubmed/30290271
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nbd.2018.09.026
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