Allergen-specific IgE levels and the ability of IgE-allergen complexes to cross-link determine the extent of CD23-mediated T-cell activation

BACKGROUND: CD23 mediates IgE-facilitated allergen presentation and subsequent allergen-specific T-cell activation in allergic patients. OBJECTIVE: We sought to investigate key factors regulating IgE-facilitated allergen presentation through CD23 and subsequent T-cell activation. METHODS: To study T...

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Publicado no:J Allergy Clin Immunol
Main Authors: Villazala-Merino, Sergio, Rodriguez-Dominguez, Azahara, Stanek, Victoria, Campion, Nicholas J., Gattinger, Pia, Hofer, Gerhard, Froeschl, Renate, Fae, Ingrid, Lupinek, Christian, Vrtala, Susanne, Breiteneder, Heimo, Keller, Walter, Perkmann, Thomas, Nakamura, Ryosuke, Pickl, Winfried F., Valenta, Rudolf, Eckl-Dorna, Julia, Niederberger, Verena
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7104374/
https://ncbi.nlm.nih.gov/pubmed/31775017
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jaci.2019.11.019
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