Spatiotemporal gating of SIRT1 functions by O-GlcNAcylation is essential for liver metabolic switching and prevents hyperglycemia

Inefficient physiological transitions are known to cause metabolic disorders. Therefore, investigating mechanisms that constitute molecular switches in a central metabolic organ like the liver becomes crucial. Specifically, upstream mechanisms that control temporal engagement of transcription factor...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Chattopadhyay, Tandrika, Maniyadath, Babukrishna, Bagul, Hema P., Chakraborty, Arindam, Shukla, Namrata, Budnar, Srikanth, Rajendran, Abinaya, Shukla, Arushi, Kamat, Siddhesh S., Kolthur-Seetharam, Ullas
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2020
Assuntos:
PNAS Plus
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7104039/
https://ncbi.nlm.nih.gov/pubmed/32152092
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1909943117
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