Spatiotemporal gating of SIRT1 functions by O-GlcNAcylation is essential for liver metabolic switching and prevents hyperglycemia

Inefficient physiological transitions are known to cause metabolic disorders. Therefore, investigating mechanisms that constitute molecular switches in a central metabolic organ like the liver becomes crucial. Specifically, upstream mechanisms that control temporal engagement of transcription factor...

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Bibliografische gegevens
Gepubliceerd in:Proc Natl Acad Sci U S A
Hoofdauteurs: Chattopadhyay, Tandrika, Maniyadath, Babukrishna, Bagul, Hema P., Chakraborty, Arindam, Shukla, Namrata, Budnar, Srikanth, Rajendran, Abinaya, Shukla, Arushi, Kamat, Siddhesh S., Kolthur-Seetharam, Ullas
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: National Academy of Sciences 2020
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PNAS Plus
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7104039/
https://ncbi.nlm.nih.gov/pubmed/32152092
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1909943117
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