MDA5 Detects the Double-Stranded RNA Replicative Form in Picornavirus-Infected Cells

RIG-I and MDA5 are cytosolic RNA sensors that play a critical role in innate antiviral responses. Major advances have been made in identifying RIG-I ligands, but our knowledge of the ligands for MDA5 remains restricted to data from transfection experiments mostly using poly(I:C), a synthetic dsRNA m...

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Pubblicato in:Cell Rep
Autori principali: Feng, Qian, Hato, Stanleyson V., Langereis, Martijn A., Zoll, Jan, Virgen-Slane, Richard, Peisley, Alys, Hur, Sun, Semler, Bert L., van Rij, Ronald P., van Kuppeveld, Frank J.M.
Natura: Artigo
Lingua:Inglês
Pubblicazione: The Authors. Published by Elsevier Inc. 2012
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7103987/
https://ncbi.nlm.nih.gov/pubmed/23142662
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2012.10.005
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