Regulation of the RNAPII Pool Is Integral to the DNA Damage Response

In response to transcription-blocking DNA damage, cells orchestrate a multi-pronged reaction, involving transcription-coupled DNA repair, degradation of RNA polymerase II (RNAPII), and genome-wide transcription shutdown. Here, we provide insight into how these responses are connected by the finding...

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Publicado no:Cell
Main Authors: Tufegdžić Vidaković, Ana, Mitter, Richard, Kelly, Gavin P., Neumann, Michelle, Harreman, Michelle, Rodríguez-Martínez, Marta, Herlihy, Anna, Weems, Juston C., Boeing, Stefan, Encheva, Vesela, Gaul, Liam, Milligan, Laura, Tollervey, David, Conaway, Ronald C., Conaway, Joan W., Snijders, Ambrosius P., Stewart, Aengus, Svejstrup, Jesper Q.
Formato: Artigo
Idioma:Inglês
Publicado em: Cell Press 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7103762/
https://ncbi.nlm.nih.gov/pubmed/32142654
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2020.02.009
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