Acute Pannexin 1 Blockade Mitigates Early Synaptic Plasticity Defects in a Mouse Model of Alzheimer’s Disease

Synaptic loss induced by soluble oligomeric forms of the amyloid β peptide (sAβos) is one of the earliest events in Alzheimer’s disease (AD) and is thought to be the major cause of the cognitive deficits. These abnormalities rely on defects in synaptic plasticity, a series of events manifested as ac...

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Publicat a:Front Cell Neurosci
Autors principals: Flores-Muñoz, Carolina, Gómez, Bárbara, Mery, Elena, Mujica, Paula, Gajardo, Ivana, Córdova, Claudio, Lopez-Espíndola, Daniela, Durán-Aniotz, Claudia, Hetz, Claudio, Muñoz, Pablo, Gonzalez-Jamett, Arlek M., Ardiles, Álvaro O.
Format: Artigo
Idioma:Inglês
Publicat: Frontiers Media S.A. 2020
Matèries:
Cellular Neuroscience
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7103637/
https://ncbi.nlm.nih.gov/pubmed/32265655
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fncel.2020.00046
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