Acute Pannexin 1 Blockade Mitigates Early Synaptic Plasticity Defects in a Mouse Model of Alzheimer’s Disease

Synaptic loss induced by soluble oligomeric forms of the amyloid β peptide (sAβos) is one of the earliest events in Alzheimer’s disease (AD) and is thought to be the major cause of the cognitive deficits. These abnormalities rely on defects in synaptic plasticity, a series of events manifested as ac...

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Detalhes bibliográficos
Publicado no:Front Cell Neurosci
Main Authors: Flores-Muñoz, Carolina, Gómez, Bárbara, Mery, Elena, Mujica, Paula, Gajardo, Ivana, Córdova, Claudio, Lopez-Espíndola, Daniela, Durán-Aniotz, Claudia, Hetz, Claudio, Muñoz, Pablo, Gonzalez-Jamett, Arlek M., Ardiles, Álvaro O.
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2020
Assuntos:
Cellular Neuroscience
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7103637/
https://ncbi.nlm.nih.gov/pubmed/32265655
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fncel.2020.00046
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