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Single amino acid change underlies distinct roles of H2A.Z subtypes in human syndrome
Developmental disorder Floating-Harbor Syndrome (FHS) is caused by heterozygous truncating mutations in SRCAP, a gene encoding a chromatin remodeler mediating incorporation of histone variant H2A.Z. Here, we demonstrate that FHS-associated mutations result in loss of SRCAP nuclear localization, alte...
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| Publicado en: | Cell |
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| Autores principales: | , , , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
2019
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7103420/ https://ncbi.nlm.nih.gov/pubmed/31491386 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2019.08.002 |
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