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Single amino acid change underlies distinct roles of H2A.Z subtypes in human syndrome
Developmental disorder Floating-Harbor Syndrome (FHS) is caused by heterozygous truncating mutations in SRCAP, a gene encoding a chromatin remodeler mediating incorporation of histone variant H2A.Z. Here, we demonstrate that FHS-associated mutations result in loss of SRCAP nuclear localization, alte...
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| Udgivet i: | Cell |
|---|---|
| Main Authors: | , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2019
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7103420/ https://ncbi.nlm.nih.gov/pubmed/31491386 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2019.08.002 |
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