Poly(ADP-ribosyl)ation mediates early phase histone eviction at DNA lesions

Nucleosomal histones are barriers to the DNA repair process particularly at DNA double-strand breaks (DSBs). However, the molecular mechanism by which these histone barriers are removed from the sites of DNA damage remains elusive. Here, we have generated a single specific inducible DSB in the cells...

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Vydáno v:Nucleic Acids Res
Hlavní autoři: Yang, Guang, Chen, Yibin, Wu, Jiaxue, Chen, Shih-Hsun, Liu, Xiuhua, Singh, Anup Kumar, Yu, Xiaochun
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2020
Témata:
Genome Integrity, Repair and Replication
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7102957/
https://ncbi.nlm.nih.gov/pubmed/31965183
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkaa022
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