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Mycobacterial DNA polymerase I: activities and crystal structures of the POL domain as apoenzyme and in complex with a DNA primer-template and of the full-length FEN/EXO–POL enzyme

Mycobacterial Pol1 is a bifunctional enzyme composed of an N-terminal DNA flap endonuclease/5′ exonuclease domain (FEN/EXO) and a C-terminal DNA polymerase domain (POL). Here we document additional functions of Pol1: FEN activity on the flap RNA strand of an RNA:DNA hybrid and reverse transcriptase...

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Detalles Bibliográficos
Publicado en:Nucleic Acids Res
Main Authors: Ghosh, Shreya, Goldgur, Yehuda, Shuman, Stewart
Formato: Artigo
Idioma:Inglês
Publicado: Oxford University Press 2020
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7102940/
https://ncbi.nlm.nih.gov/pubmed/32034423
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkaa075
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