Dopamine deficiency reduces striatal cholinergic interneuron function in models of Parkinson’s disease

Motor and cognitive functions depend on the coordinated interactions between dopamine (DA) and acetylcholine (ACh) at striatal synapses. Increased ACh availability was assumed to accompany DA deficiency based on the outcome of pharmacological treatments and measurements in animals that were critical...

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Publicado no:Neuron
Main Authors: McKinley, Jonathan W., Shi, Ziqing, Kawikova, Ivana, Hur, Matthew, Bamford, Ian J., Sudarsana Devi, Suma Priya, Vahedipour, Annie, Darvas, Martin, Bamford, Nigel S.
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7102938/
https://ncbi.nlm.nih.gov/pubmed/31324539
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuron.2019.06.013
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