Mutant lamins cause nuclear envelope rupture and DNA damage in skeletal muscle cells

Mutations in the LMNA gene, which encodes the nuclear envelope (NE) proteins lamins A/C, cause Emery-Dreifuss muscular dystrophy, congenital muscular dystrophy, and other diseases collectively known as laminopathies. The mechanisms responsible for these diseases remain incompletely understood. Using...

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Pubblicato in:Nat Mater
Autori principali: Earle, Ashley J., Kirby, Tyler J., Fedorchak, Gregory R., Isermann, Philipp, Patel, Jineet, Iruvanti, Sushruta, Moore, Steven A., Bonne, Gisèle, Wallrath, Lori L., Lammerding, Jan
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2019
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7102937/
https://ncbi.nlm.nih.gov/pubmed/31844279
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41563-019-0563-5
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