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Genetic deficiency and polymorphisms of cyclophilin A reveal its essential role for Human Coronavirus 229E replication
Replication of coronaviruses is inhibited in vitro by cyclosporin A, a well-known immunosuppressive drug which binds to cellular cyclophilins thus inactivating their enzymatic cis-trans peptidyl-prolyl isomerase function. Latter is required for proper folding of cellular proteins and of proteins of...
Gespeichert in:
| Veröffentlicht in: | Curr Opin Virol |
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| Hauptverfasser: | , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Elsevier B.V.
2015
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7102849/ https://ncbi.nlm.nih.gov/pubmed/26318518 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.coviro.2015.08.004 |
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