TGF-β type 2 receptor–mediated modulation of the IL-36 family can be therapeutically targeted in osteoarthritis

Mechanisms that govern the shift from joint homeostasis to osteoarthritis (OA) remain unknown. Here, we identify a pathway used for joint development and homeostasis, and its role in OA. Using a combination of transgenic, pharmacological, and surgical conditions in mouse and human tissues, we found...

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Vydáno v:Sci Transl Med
Hlavní autoři: Li, Tieshi, Chubinskaya, Susan, Esposito, Alessandra, Jin, Xin, Tagliafierro, Lidia, Loeser, Richard, Hakimiyan, Arnavaz A., Longobardi, Lara, Ozkan, Huseyin, Spagnoli, Anna
Médium: Artigo
Jazyk:Inglês
Vydáno: 2019
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7102613/
https://ncbi.nlm.nih.gov/pubmed/31068441
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.aan2585
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