TGF-β type 2 receptor–mediated modulation of the IL-36 family can be therapeutically targeted in osteoarthritis

Mechanisms that govern the shift from joint homeostasis to osteoarthritis (OA) remain unknown. Here, we identify a pathway used for joint development and homeostasis, and its role in OA. Using a combination of transgenic, pharmacological, and surgical conditions in mouse and human tissues, we found...

Fuld beskrivelse

Na minha lista:
Bibliografiske detaljer
Udgivet i:Sci Transl Med
Main Authors: Li, Tieshi, Chubinskaya, Susan, Esposito, Alessandra, Jin, Xin, Tagliafierro, Lidia, Loeser, Richard, Hakimiyan, Arnavaz A., Longobardi, Lara, Ozkan, Huseyin, Spagnoli, Anna
Format: Artigo
Sprog:Inglês
Udgivet: 2019
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7102613/
https://ncbi.nlm.nih.gov/pubmed/31068441
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.aan2585
Tags: Tilføj Tag
Ingen Tags, Vær først til at tagge denne postø!

Lignende værker