Cellular and molecular architecture of hematopoietic stem cells and progenitors in genetic models of bone marrow failure

Inherited bone marrow failure syndromes, such as Fanconi anemia (FA) and Shwachman-Diamond syndrome (SDS), feature progressive cytopenia and a risk of acute myeloid leukemia (AML). Using deep phenotypic analysis of early progenitors in FA/SDS bone marrow samples, we revealed selective survival of pr...

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Publicat a:JCI Insight
Autors principals: Heidemann, Stephanie, Bursic, Brian, Zandi, Sasan, Li, Hongbing, Abelson, Sagi, Klaassen, Robert J., Abish, Sharon, Rayar, Meera, Breakey, Vicky R., Moshiri, Houtan, Dhanraj, Santhosh, de Borja, Richard, Shlien, Adam, Dick, John E., Dror, Yigal
Format: Artigo
Idioma:Inglês
Publicat: American Society for Clinical Investigation 2020
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7101147/
https://ncbi.nlm.nih.gov/pubmed/31990679
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.131018
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