Genomic evidence supports a clonal diaspora model for metastases of esophageal adenocarcinoma

The poor outcomes in esophageal adenocarcinoma (EAC) prompted us to interrogate the pattern and timing of metastatic spread. Whole genome sequencing and phylogenetic analysis of 388 samples across 18 EAC cases demonstrated in 90% of cases that multiple subclones from the primary tumor spread very ra...

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Udgivet i:Nat Genet
Main Authors: Noorani, Ayesha, Li, Xiaodun, Goddard, Martin, Crawte, Jason, Alexandrov, Ludmil B., Secrier, Maria, Eldridge, Matthew D., Bower, Lawrence, Weaver, Jamie, Lao-Sirieix, Pierre, Martincorena, Inigo, Debiram-Beecham, Irene, Grehan, Nicola, MacRae, Shona, Malhotra, Shalini, Miremadi, Ahmad, Thomas, Tabitha, Galbraith, Sarah, Petersen, Lorraine, Preston, Stephen D., Gilligan, David, Hindmarsh, Andrew, Hardwick, Richard H., Stratton, Michael R., Wedge, David C., Fitzgerald, Rebecca C.
Format: Artigo
Sprog:Inglês
Udgivet: 2020
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7100916/
https://ncbi.nlm.nih.gov/pubmed/31907488
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41588-019-0551-3
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