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TDP-43 promotes the formation of neuromuscular synapses through the regulation of Disc-large expression in Drosophila skeletal muscles

BACKGROUND: The ribonuclear protein TDP-43 has been implicated in the pathophysiology of amyotrophic lateral sclerosis (ALS), with genetic mutations being linked to the neurological symptoms of the disease. Though alterations in the intracellular distribution of TDP-43 have been observed in skeletal...

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Publicat a:BMC Biol
Autors principals: Strah, Nina, Romano, Giulia, Introna, Clelia, Klima, Raffaella, Marzullo, Marta, Ciapponi, Laura, Megighian, Aram, Nizzardo, Monica, Feiguin, Fabian
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2020
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7099817/
https://ncbi.nlm.nih.gov/pubmed/32216790
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12915-020-00767-7
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