Loss of circadian gene Bmal1 in the collecting duct lowers blood pressure in male, but not female, mice

Kidney function follows a 24-h rhythm subject to regulation by circadian genes including the transcription factor Bmal1. A high-salt diet induces a phase shift in Bmal1 expression in the renal inner medulla that is dependent on endothelin type B (ET(B)) receptors. Furthermore, ET(B) receptor-mediate...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Am J Physiol Renal Physiol
Prif Awduron: Zhang, Dingguo, Jin, Chunhua, Obi, Ijeoma E., Rhoads, Megan K., Soliman, Reham H., Sedaka, Randee S., Allan, J. Miller, Tao, Binli, Speed, Joshua S., Pollock, Jennifer S., Pollock, David M.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Physiological Society 2020
Pynciau:
Research Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC7099501/
https://ncbi.nlm.nih.gov/pubmed/31904281
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajprenal.00364.2019
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