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Transformation Foci in IDH1-mutated Gliomas Show STAT3 Phosphorylation and Downregulate the Metabolic Enzyme ETNPPL, a Negative Regulator of Glioma Growth

IDH1-mutated gliomas are slow-growing brain tumours which progress into high-grade gliomas. The early molecular events causing this progression are ill-defined. Previous studies revealed that 20% of these tumours already have transformation foci. These foci offer opportunities to better understand m...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Leventoux, N., Augustus, M., Azar, S., Riquier, S., Villemin, J. P., Guelfi, S., Falha, L., Bauchet, L., Gozé, C., Ritchie, W., Commes, T., Duffau, H., Rigau, V. , Hugnot, J. P.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2020
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7099072/
https://ncbi.nlm.nih.gov/pubmed/32218467
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-62145-1
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