The secreted protease Adamts18 links hormone action to activation of the mammary stem cell niche

Estrogens and progesterone control breast development and carcinogenesis via their cognate receptors expressed in a subset of luminal cells in the mammary epithelium. How they control the extracellular matrix, important to breast physiology and tumorigenesis, remains unclear. Here we report that bot...

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Gepubliceerd in:Nat Commun
Hoofdauteurs: Ataca, Dalya, Aouad, Patrick, Constantin, Céline, Laszlo, Csaba, Beleut, Manfred, Shamseddin, Marie, Rajaram, Renuga Devi, Jeitziner, Rachel, Mead, Timothy J., Caikovski, Marian, Bucher, Philipp, Ambrosini, Giovanna, Apte, Suneel S., Brisken, Cathrin
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Nature Publishing Group UK 2020
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7099066/
https://ncbi.nlm.nih.gov/pubmed/32218432
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-15357-y
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